Article updated: 2021 Mar 19 / Author Leslie Griver, Robert Henry

Best Vitamins to Detox THC

Here we will list vitamins that help detox THC and vitamins that help to flush THC.

These two methods use different approaches and require different vitamins and supplements.

Detox means the permanent removal of THC from the system. Flushing means temporary THC removal from the urine for a drug test.

Best vitamins for THC detox

To get weed out of your system completely, you should speed up the fat burning and improve THC metabolism in the liver. Burning fat will release THC stored in body fat cells. Improving liver metabolism will speed up the removal of THC from the blood.

You should understand that vitamin supplementation alone may not speed up fat burning. It has to come from lifestyle changes as well.

If fat burning was as easy as taking a supplement, we could settle on the couch and watch Netflix while the supplement did all the work.

B vitamins

The B vitamins’ primary function is to help your body metabolize carbohydrates, proteins, and fats.

Low levels of one or more of these vitamins mean your metabolism won’t be functioning at its best. This makes burning fat even harder.

Sources of B vitamins: beans, eggs, lean meat, whole grains, potatoes

Vitamin D

According to research, vitamin D may prevent depression. A positive attitude is also essential for an effective diet.

A 2011 study found that overweight and obese adults taking calcium and vitamin D supplements lost significantly more stomach fat than people not taking any supplements.

Sources of D vitamins: While the sun is the best source of vitamin D, sardines, tuna, salmon, egg yolk


Iron helps carry oxygen to all of the cells in your body, including your muscles. This, in turn, helps them burn fat.

Low iron levels also reduce your physical endurance and athletic performance.

Source: lean meats, shellfish, beans, spinach


Caffeine is a primary ingredient in just about every fat-burning supplement.

It increase metabolism and boosts the breakdown of fatty acids.

One study with over 58,000 people found that increased caffeine intake was associated with less weight gain over a 12-year period

Another study found that higher caffeine intake was linked to a higher rate of success with weight loss maintenance among 2623 people

St. John’s Wort

This is the most famous herb for inducing enzymes responsible for phase 1 of THC metabolism. It is well researched, and several studies confirm its properties.

This research shows that St John’s Wort induces(increase the activity) CYP3A4 enzymes.

“St. John’s Wort Affects cytochrome P450 isoforms increasing metabolic activity CYP3A4 and CYP2C9.”


“St. John’s wort affects the pharmacokinetics of several drugs by inducing CYP isozymes, such as CYP3A4, CYP2C19, CYP2C9”.


Panax Ginseng

There was a study with 12 people involved. They 500mg of Panax Ginseng twice daily for 28 days. The results showed that Panax ginseng induced CYP3A activity in the liver and possibly the gastrointestinal tract.

Ginkgo Biloba

The study with 14 people showed that the Ginkgo Biloba extract moderately induces the CYP2C19 enzyme. But this only occurred at the highest recommended dose of 240mg/day.

Another study showed that the G. Biloba Extract at 100-2,500 ng/ml significantly induced the activity and expression of CYP3A.

Best vitamins to flush THC

To flush THC, we need something that slows down the activity of metabolizing enzymes. We also need something to restore natural urine parameters like color, specific gravity, and creatinine levels.

Vitamin B2

Riboflavin (B2) is essential if you do flushing. It will restore the natural yellow color of the urine about 2 hours after consumption.

Creatine ethyl ester

It will restore creatinine levels in the urine. You can use a creatine monohydrate supplement, but it will take more time to work.

Echinacea, Saw Palmetto, Ginger

Well, these are not actually vitamins. But several studies confirm that these herbs are effective inhibitors of CYP3A4, CYP2C19, CYP2C9 enzymes. This means that they will slow THC metabolism in the liver and prevent new metabolites from getting into the urine


First of all, you need to decide if you need to detox THC or flush THC from your system. In both cases, you’ll need Vitamin B. Choose other vitamins and supplements according to the selected method.